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Biomanufacturing in low Earth orbit for regenerative medicine
Arun Sharma (Cedars-Sinai Medical Center, Cedars-Sinai Smidt Heart Institute), Rachel A. Clemens, Orquidea Garcia (Johnson & Johnson (United States)), D. Lansing Taylor (University of Pittsburgh, The Ohio State University), Nicole L. Wagner, Kelly A. Shepard (California Institute for Regenerative Medicine), Anjali E. Gupta, Siobhan Malany (University of Florida), Alan Jay Grodzinsky (Massachusetts Institute of Technology), Mary Kearns‐Jonker (Loma Linda University), Devin B. Mair (Johns Hopkins University), Deok‐Ho Kim (Johns Hopkins University, Johns Hopkins Medicine), Michael S. Roberts (Center for the Advancement of Science in Space), Jeanne F. Loring (Scripps Research Institute), Jianying Hu (IBM (United States), IBM Research - Thomas J. Watson Research Center), L. E. Warren (Center for the Advancement of Science in Space), Sven Eenmaa (Center for the Advancement of Science in Space), Joe Bozada (University of Pittsburgh), Eric Paljug (University of Pittsburgh), Mark Roth, Donald P. Taylor (University of Pittsburgh, The Ohio State University), Gary Rodrigue (Center for the Advancement of Science in Space), Patrick Cantini (McGowan Institute for Regenerative Medicine), Amelia W. Smith (Center for the Advancement of Science in Space), Marc A. Giulianotti (Center for the Advancement of Science in Space), William Richard Wagner (University of Pittsburgh, McGowan Institute for Regenerative Medicine)
Abstract: Research in low Earth orbit (LEO) has become more accessible. The 2020 Biomanufacturing in Space Symposium reviewed space-based regenerative medicine research and discussed leveraging LEO to advance biomanufacturing for regenerative medicine applications. The symposium identified areas where financial investments could stimulate advancements overcoming technical barriers. Opportunities in disease modeling, stem-cell-derived products, and biofabrication were highlighted. The symposium will initiate a roadmap to a sustainable market for regenerative medicine biomanufacturing in space. This perspective summarizes the 2020 Biomanufacturing in Space Symposium, highlights key biomanufacturing opportunities in LEO, and lays the framework for a roadmap to regenerative medicine biomanufacturing in space.