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Additive Biomanufacturing with Collagen Inks
Weng Wan Chan (Agency for Science, Technology and Research, Bioprocessing Technology Institute), David Yeo (Agency for Science, Technology and Research, Bioprocessing Technology Institute), Vernice Tan (Agency for Science, Technology and Research, Bioprocessing Technology Institute), Satnam Singh (Agency for Science, Technology and Research, Bioprocessing Technology Institute), Deepak Choudhury (Agency for Science, Technology and Research, Bioprocessing Technology Institute), May Win Naing (Agency for Science, Technology and Research, Singapore Institute of Manufacturing Technology)
Abstract: Collagen is a natural polymer found abundantly in the extracellular matrix (ECM). It is easily extracted from a variety of sources and exhibits excellent biological properties such as biocompatibility and weak antigenicity. Additionally, different processes allow control of physical and chemical properties such as mechanical stiffness, viscosity and biodegradability. Moreover, various additive biomanufacturing technology has enabled layer-by-layer construction of complex structures to support biological function. Additive biomanufacturing has expanded the use of collagen biomaterial in various regenerative medicine and disease modelling application (e.g., skin, bone and cornea). Currently, regulatory hurdles in translating collagen biomaterials still remain. Additive biomanufacturing may help to overcome such hurdles commercializing collagen biomaterials and fulfill its potential for biomedicine.